CURRICULUM VITAE

Qualification:

• 1963: B. Sci., Chemistry, Moscow Institute of Chemical Technology;
• 1971: Ph.D., Physical Chemistry of Polymers, Moscow, Institute of Organoelement Compounds, USSR Academy of Sciences;
• 1988: Dr. Sci., Physical Chemistry of Polymers, Moscow, Institute of Organoelement Compounds, USSR Academy of Sciences.

Current Position: Head of the Laboratory of Protein Systems at N.M. Emanuel Institute of Biochemical Physics of Russian Academy of Sciences.

Business Address: N.M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, Vavilov Str. 28; 119991, GSP-1, Moscow V-334, Russian Federation; FAX: 007(095)135-44-06; TEL: 007(095)135-64-57 (office); E-MAIL: grinberg@ineos.ac.ru.

Home Address: 2 Tchelomej St., flat 132, 117630, Moscow V-630, Russia; TEL: 007(095) 936-37-96.

Brief statement of scientific career:

• Since 2006: Senior researcher, Laboratory of physical chemistry of polymers, AN Nesmeyanov Institute of Organo-Element Compounds, Russian Academy of Sciences;
• 1996-2006: Head of the Laboratory of Protein Systems, N.M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences;
• 1991-1995: Head of the Laboratory of Food Protein Systems, Institute of Food Substances, Russian Academy of Sciences;
• 1988: awarded Dr. Sci. degree from Moscow Institute of Organoelement Compounds, USSR Academy of Sciences, for research in the field of thermodynamics and rheology of food protein systems;
• 1986-91: Senior Researcher, Laboratory of Novel Food Forms, Institute of Organoelement Compounds, USSR Academy of Sciences;
• 1971-85: Researcher, Laboratory of Novel Food Forms, Institute of Organoelement Compounds, USSR Academy of Sciences;
• 1971: obtained Ph.D. from Moscow Institute of Organoelement Compounds, USSR Academy of Sciences, for research in field of thermodynamic incompatibility of food biopolymers;
• 1963: graduated from Moscow Institute of Chemical Technology.

Research Interest: Thermodynamics of conformational and phase transitions in solutions and gels of polymers including biopolymers.

Publications: About 150 research papers, reviews and patents covering above indicated aspects.

List of recent publications:

1. Feldstein, M.M., Bovaldinova, K.A., Bermesheva, E.V., Moscalets, A.P., Dormidontova, E.E., Grinberg, V.Y., Khokhlov, A.R., Thermo-Switchable Pressure-Sensitive Adhesives Based on Poly(N-vinyl caprolactam) Non-Covalently Cross-Linked by Poly(ethylene glycol), Macromolecules 2014, 47, 5759.
2. Alvarez-Lorenzo, C., Concheiro, A. , Dubovik, A.S., Grinberg, N.V., Burova, T.V., Grinberg, V.Ya., Temperature-sensitive chitosan-poly(N-isopropylacrylamide) interpenetrated networks with enhanced loading capacity and controlled release properties, J. Controlled Release 2005, 102, 629.
3. Burova, T.V., Grinberg, N.V., Grinberg, V.Ya., Kalinina, E.V., Lozinsky, V.I., Aseev, V.O., Holappa, S., Tenhu, H., Khokhlov, A.R., Unusual conformational behavior of complexes of poly(N-isopropylacrylamide) with poly(methacrylic acid), Macromolecules 2005, 38, 1292.
4. Burova, T.V., Grinberg, N.V., Dubovik, A.S., Alvarez-Lorenzo, C., Grinberg, V.Ya., Grosberg, A.Yu., Energetics of ligand binding to protein-like polymer systems. Pyranine-4 / [N-isopropylacrylamide - N-(3-aminopropyl)methacrylamide hydrochloride] copolymer system, 3rd All-Russian Kargin Conference “Polymers – 2004”, Moscow, Moscow State University Publisher, 27.1.2004, v. 1, p. 256.
5. Burova, T.V., Grinberg, N.V., Grinberg, V.Ya., Zhang, G., Wu, C., Polyelectrolyte complexing of thermoresponsive copolymer with lysozyme: how does it affect protein conformation and copolymer phase transition?, 40th International Symposium on Macromolecules “MACRO 2004”, Paris, 4.7.2004.
6. Burova, T.V., Grinberg, N.V., Grinberg, V.Ya., Kalinina, E.V., Lozinsky, V.I., Aseev, V.O., Holappa, S., Tenhu, H., Complexes of poly(N-isopropylacrylamide) with poly(methacrylic acid): conformational and phase transitions, 40th International Symposium on Macromolecules “MACRO 2004”, Paris, 4.7.2004.
7. Burova, T.V., Grinberg, N.V., Dubovik, A.S., Tanaka, K., Grinberg, V.Y., Grosberg, A.Y., Effects of ligand binding on relative stability of subchain conformations of weakly charged N-isopropylacrylamide gels in swollen and shrunken states, Macromolecules 2003, 36, 9115.
8. Grinberg, V.Y., Burova, T.V., Grinberg, N.V., Mashkevich, A.Y., Plashchina, I.G., Usov, A.I., Shusharina, N.P., Khokhlov, A.R., Navarini, L., Cesaro, A., Thermodynamics of the double helix-coil equilibrium in tetramethylammonium gellan: high-sensitivity differential scanning calorimetry data, Macromol. Biosci. 2003, 3, 169.
9. Lozinsky, V.I., Simenel, I.A., Kulakova, V.K., Kurskaya, E.A., Babushkina, T.A., Klimova, T.P., Burova, T.V., Dubovik, A.S., Grinberg, V.Ya., Galaev, I.Y., Mattiasson, B., Khokhlov, A.R., Synthesis and studies of N-vinylcaprolactam/N-vinylimidazole copolymers that exhibit the "protein-like" behaviour in aqueous media, Macromolecules 2003, 36, 7308.
10. Mikheeva, L.M., Grinberg, N.V., Grinberg, V.Y., Khokhlov, A.R., de Kruif, C.G., Thermodynamics of micellization of bovine beta-casein studied by high-sensitivity differential scanning calorimetry, Langmuir 2003, 19, 2913.
11. O'Connell, J.E., Grinberg, V.Y., de Kruif, C.G., Association behavior of beta-casein, J. Coll. Interface Sci. 2003, 258, 33.
12. Burova, T.V., Grinberg, N.V., Visschers, R.W., Grinberg, V.Y., de Kruif, C.G., Thermodynamic stability of porcine beta-lactoglobulin - A structural relevance, Eur. J. Biochem. 2002, 269, 3958.
13. Burova, T.V., Varfolomeeva, E.P., Grinberg, V.Y., Haertle, T., Tolstoguzov, V.B., Effects of polysaccharides on the stability and renaturation of soybean trypsin (Kunitz) inhibitor, Macromol. Biosci. 2002.
14. de Kruif, C.G., Grinberg, V.Y., Micellisation of beta-casein, Colloids and Surfaces A 2002, 210, 183.
15. Lozinsky, V.I., Kalinina, E.V., Putilina, O.I., Kulakova, V.K., Kurskaya, E.A., Dubovik, A.S., Grinberg, V.Y., Effect of the phase state of a reaction mixture on the properties of poly(N-isopropylacrylamide) synthesized in an aqueous medium, Polymer Sci. A 2002, 44, 1122.
16. Van de Velde, F., Rollema, H.S., Grinberg, N.V., Burova, T.V., Grinberg, V.Y., Tromp, R.H., Coil-helix transition of iota-carrageenan as a function of chain regularity, Biopolymers 2002, 65, 299.
17. Grinberg, A.V., Gevondyan, N.M., Grinberg, N.V., Grinberg, V.Y., The thermal unfolding and domain structure of Na+/K+-exchanging ATPase - A scanning calorimetry study, Eur. J. Biochem. 2001, 268, 5027.
18. Grinberg, V.Y., Grinberg, N.V., Usov, A.I., Shusharina, N.P., Khokhlov, A.R., de Kruif, K.G., Thermodynamics of conformational ordering of iota-carrageenan in KCl solutions using high-sensitivity differential scanning calorimetry, Biomacromolecules 2001, 2, 864.
19. Vinogradov, A.A., Kudryashova, E.V., Grinberg, V.Y., Grinberg, N.V., Burova, T.V., Levashov, A.V., The chemical modification of alpha-chymotrypsin with both hydrophobic and hydrophilic compounds stabilizes the enzyme against denaturation in water-organic media, Protein Eng. 2001, 14, 683.
20. Burova, T.V., Grinberg, N.V., Grinberg, V.Y., Rariy, R.V., Klibanov, A.M., Calorimetric evidence for a native-like conformation of hen egg-white lysozyme dissolved in glycerol, Biochim. Biophys. Acta 2000, 1478, 309.
21. Grinberg, V.Y., Burova, T.V., Haertle, T., Tolstoguzov, V.B., Interpretation of DSC data on protein denaturation complicated by kinetic and irreversible effects, J. Biotechnol. 2000, 79, 269.
22. Grinberg, V.Y., Dubovik, A.S., Kuznetsov, D.V., Grinberg, N.V., Grosberg, A.Y., Tanaka, T., Studies of the thermal volume transition of poly(N-isopropylacrylamide) hydrogels by high-sensitivity differential scanning microcalorimetry. 2. Thermodynamic functions, Macromolecules 2000, 33, 8685.
23. Lozinskii, V.I., Simenel, I.A., Kurskaya, E.A., Kulakova, V.K., Grinberg, V.Y., Dubovik, A.S., Galaev, I.Y., Mattiasson, B., Khokhlov, A.R., Synthesis and properties of a "protein-like" copolymer, Doklady Chemistry 2000, 375, 273.
24. Lozinsky, V.I., Simenel, I.A., Kurskaya, E.A., Kulakova, V.K., Galaev, I.Y., Mattiasson, B., Grinberg, V.Y., Grinberg, N.V., Khokhlov, A.R., Synthesis of N-vinylcaprolactam polymers in water-containing media, Polymer 2000, 41, 6507.
25. Grinberg, N.V., Dubovik, A.S., Grinberg, V.Y., Kuznetsov, D.V., Makhaeva, E.E., Grosberg, A.Y., Tanaka, T., Studies of the thermal volume transition of poly(N-isopropylacrylamide) hydrogels by high-sensitivity differential scanning microcalorimetry. 1. Dynamic effects, Macromolecules 1999, 32, 1471.
26. Grinberg, V.Y., Grinberg, N.V., Mikheeva, L.M., Dembo, A.T., Makhaeva, E.E., Khokhlov, A.R., Grosberg, A.Y., Tanaka, T., A new hydrogel system undergoing a volume phase transition upon heating, Macromol. Chem. Phys. 1999, 200, 1603.
27. Grinberg, V.Y., Grinberg, N.V., Burova, T.V., Dalgalarrondo, M., Haertle, T., Ethanol-induced conformational transitions in holo-alpha-lactalbumin: Spectral and calorimetric studies, Biopolymers 1998, 46, 253.
28. Sokolov, E., Yeh, F., Khokhlov, A., Grinberg, V.Y., Chu, B., Nanostructure formation in polyelectrolyte-surfactant complexes, J. Phys. Chem. B 1998, 102, 7091.
29. Lozinskii, V.I., Kalinina, E.V., Grinberg, V.Y., Grinberg, N.V., Chupov, V.V., Plate, N.A., Thermo-responsible cryogels based on cross-linked poly(N,N'-diethylacrylamide), Vysokomolek. Soedin. 1997, 39, 1972.
30. Mikheeva, L.M., Grinberg, N.V., Mashkevich, A.Y., Grinberg, V.Y., Thanh, L.T.M., Makhaeva, E.E., Khokhlov, A.R., Microcalorimetric study of thermal cooperative transitions in poly(N-vinylcaprolactam) hydrogels, Macromolecules 1997, 30, 2693.
31. Burova, T.V., Golubeva, I.A., Grinberg, N.V., Mashkevich, A.Y., Grinberg, V.Y., Usov, A.I., Navarini, L., Cesaro, A., Calorimetric study of the order-disorder conformational transition in succinoglycan, Biopolymers 1996, 39, 517.
32. Sochava, I.V., Grinberg, V.Y., Popello, I.A., Suchkov, V.V., The function of vitrification in native structure preservation in protein dehydration process, Biofizika 1995, 40, 48.
33. Levitsky, V.Y., Meliknubarov, N.S. , Siksnis, V.A., Grinberg, V.Y., Burova, T.V., Levashov, A.V., Mozhaev, V.V., Reversible conformational transition gives rise to zigzag temperature-dependence of the rate-constant of irreversible thermoinactivation of enzymes, Eur. J. Biochem. 1994, 219, 219.